抗HIV黏膜免疫评价方法研究进展

摘要

Mucosa is one of the most main transmission routes of HIV,and it is quite important to assess mucosal immune response for HIV vaccine effect evaluation. The assays for measuring immune response at mucosal sites in various animal models and human,including sampling methods,sample storage,types of mucosal biomarkers and measurements,are different. Thus,to estabilish a consensus set of evaluation system of mucosal response to HIV has important significance%黏膜是人类免疫缺陷病毒(human immunodeficiency virus,HIV)侵人机体最主要的途径之一,评价黏膜免疫应答对评价HIV疫苗效果至关重要.用于检测不同动物模型和人体黏膜免疫应答的方法不尽相同,包括黏膜取样方法、样品保存、黏膜标记物种类和检测等方面,因此,建立统一的抗HIV黏膜免疫应答评价系统具有重要的意义.