现代狂犬病疫苗生产用细胞和毒种:现状和前景

摘要

A major challenge for global rabies prevention and control is the lack of sufficient and affordable high quality vaccines.In contrast to the outdated nervous tissue-based techniques for rabies vaccines production,modem techniques of cell culture provide suitable substrates for virus propagation to produce high titer virus and modem high quality rabies vaccine on a large scale.Given the current scenario of only inactivated vaccines for humans,the vaccines prepared from highly cell-adapted and stable,attenuated rabies viruses are ideal candidates in the future.%对全球狂犬病预防控制的一个主要挑战是不能充分供应廉价优质的狂犬病疫苗.基于神经组织生产狂犬病疫苗的技术早已过时,现代细胞培养技术提供了适当的病毒培养基质,可以获得高滴度病毒和大规模生产高质量的现代狂犬病疫苗.目前人用疫苗仅使用灭活疫苗,用高度适应细胞的稳定的减毒狂犬病病毒生产的疫苗将是未来的理想疫苗.