KIF17:一个N-甲基-D-天冬氨酸受体的转运蛋白

摘要

Background KIF17 is a member of the kinesin-2 family proteins,which transports many large cargos along microtubule from negative to positive.Objective This review summarizes the current knowledge on the mechanism how to transport N-methyl-D-aspartate (NMDA) receptor.Content The transport mechanism of KIF17 has been studied widely in nerve cells.The critical role of KIF17 is to transport NR2B receptor,which involved in the formation of synaptic plasticity.KIF17 is linked to NR2Bcontaining vesicles via a scaffolding protein complex Mint10 by carbon-terminal domain.When arrives at the destination,CaMK Ⅱ-dependent phosphorylation of KIF17 on Ser-1029 disrupts the KIF17-Mint1 association and results in the release of the transported cargo NR2B.Additionally,KIF17 stabilize microtubules,contribute to epithelial morphogenesis and transport many cargos such as Spatial protein.Trend The fully understanding of the regulatory mechanisms of KIF and NR2B in the formation of pain may provide new prevention and treatment of pain.%背景 KIF17属于驱动蛋白2(Kinesin-2)家族成员,是沿微管由负极向正极移动的树突特异性驱动蛋白,可运转多种大分子物质.目的 就近几年来关于KIF17转运N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)受体的具体机制作一简要综述.内容 KIF17在神经细胞内的物质转运作用已被广泛研究,其最主要的作用是转运NMDA受体的2B亚基(NR2B)(形成突触可塑性的最主要的物质),KIF17通过碳末端结构域与大型支架蛋白Mint1结合而转运NR2B.到达树突末端后由钙离子/钙调素依赖性蛋白激酶Ⅱ( CaMKⅡ)对KIF17羧基端尾部结构域丝氨酸第1029位点(Ser-1029)的磷酸化可以使KIF17释放出NR2B.另外KIF17还在Spatial蛋白等的转运、上皮细胞的形态发生中起重要作用.趋向 充分了解KIF17与NR2B在疼痛形成中的调节机制可为临床预防和治疗疼痛提供新的思路.