中国陕西省农村人群血压、眼压和原发性开角型青光眼流行病学调查

摘要

AIM :To investigate the association of primary open-glaucoma (POAG), intraocular pressure (IOP) and systemic blood pressure in a rural population aged 50 years old or above in Shaanxi Province, China.METHODS: In the population-based, cross-sectional study, 1 775 (83.53%) residents, aged 50 years old or above, from 3 counties of Shaanxi Province, China, undertook an interview with a standard questionnaire and a detailed eye examination, including logarithm of the minimum angle of resolution visual acuity, slit-lamp biomicroscopy, applanation tonometry and dilated fundus examination. Two blood pressure reading in the sitting position were taken. Gonioscopy was performed if a narrower peripheral anterior chamber (less than one fourth of the corneal thickness) was indicated. Automated visual field testing was performed by participants assessed to have suspicion of glaucomatous disc damage or if IOP was 22mmHg or higher.RESULTS: IOP significantly correlated with systemic blood pressure, and both IOP and systolic blood pressure increased significantly with increasing age. No association between POAG and hypertension was found. The frequency of POAG increased significantly with lower diastolic perfusion pressure.CONCLUSION: Data in our study are accordance with those reported in other population-based studies, and confirm that lower diastolic perfusion pressure is a significant risk factor for primary open angle glaucoma.%目的:调查中国陕西省农村≥50岁人群原发性开角型青光眼、眼内压与全身血压的联系.方法:2003-07/12,采用整体随机分层抽样法在陕西省洋县、靖边县及富平县调查8 500人,其中≥50岁人群2 125人,所有受检人员均进行标准问卷调查及详细的眼科检查,包括视力检查、裂隙灯检查、测量眼压及散瞳后直接检眼镜检查眼底.受检者于坐位测量血压.若有可疑青光眼性视盘损害或眼压高于22mmHg者则应进行视野检查.结果:≥50岁人群中有1 775人完成了青光眼的相关检查,受检率为83.53%.通过相关分析,发现此人群中眼压与全身性血压有显著相关性;眼压与收缩压均随年龄的增长而显著升高.通过多因素logistic回归分析,显示原发性开角型青光眼与低舒张期灌注压有显著联系,但未发现原发性开角型青光眼与高血压的显著联系.结论:中国陕西省农村≥50岁人群中原发性开角型青光眼的患病率与中国其他报道相近.证实较低的舒张期灌注压是原发性开角型青光眼的一个重要危险因素.