接受激素替代疗法的绝经后亚洲妇女的干眼症

摘要

目的:比较接受和不接受激素替代疗法的绝经后妇女干眼症的发生情况.方法:采用横断面研究方法比较对照组和接受激素替代疗法的绝经后妇女干眼症的发生.对所有的受试者行泪液分泌实验,泪膜破裂时间和玫瑰红孟加拉染色检查.结果:总共54例妇女被纳入研究,其中接受激素替代疗法(第2组)30例(55.6%),对照组24例(44.4%)没有进行任何激素治疗(第1组).在第2组中,11例服用雌激素(2A组),其余19例同时服用雌激素和孕酮(2B组).在第1组组中有29.2%发生了干眼症,第2组为70.0%(P=0.003),进一步分析发现2B组(84.2%)较2A组(45.5%)更多发生了干眼症(P=0.042).结论:本研究发现在绝经后服用激素的妇女中干眼症比较常见,它否定了先前激素替代疗法具有防止干眼症发生的假设.%AIM: To compare the occurrence of dry eye in post-menopausal women between those taking hormone replacement therapy and those not on hormone replacement therapy (HRT).METHODS: A comparative cross sectional study was carried out to determine the occurrence of dry eye in control subjects and those on HRT. Schirmer's test, tear film break-up time and Rose Bengal staining were performed on all participants.RESULTS: Fifty-four women were examined. Among them 30 (55.6%) were on hormone replacement therapy (Group 2), while the control group consists of 24 (44.4%) women not on any hormone replacement therapy (Group 1). In Group 2 (HRT), 11 patients were on estrogen (Group 2A) and 19 patients were on combined estrogen and progesterone (Group 2B). Dry eye was found in 29.2% of patients in Group 1 (Control) and in 70.0% of patients in Group 2 (HRT) (P =0.003). In Group 2 (HRT),dry eye was more common in Group 2B, 84.2% compared to Group 2A, 45.5% (P =0.042).CONCLUSION: Dry eye was found more commonly in post-menopausal women who took HRT in our study population. Our finding has negated the previous assumption that HRT is a protective factor against dry eye.