OCT诊断原发性青光眼价值的Meta分析

摘要

AIM: To analyze the the ability of optical coherence tomography ( OCT ) in diagnosis of primary glaucoma through evidence-based medicine, the application of a variety of evaluation and statistical analysis model, provide a reasonable selection of reference to clinicians diagnose glaucoma diagnostic method. n METHODS: The method according to Cochrane systematic reviews, systematic and comprehensive literature was searched PubMed, Web of Science, Medalink, CNKI, CBM, Wanfang Data. Collect all OCT relevant diagnostic test, the quality assessment of diagnostic accuracy studies ( QUADAS) items were used to assess the quality of the included studies. The Meta-Disc software was used to analyze the data. n RESULTS: A total of 16 trials were included, The results of Meta - analyses showed that the summary sensitivity, specificity and 95% CI were 0. 86 (0. 84~0. 88), 0.90(0. 88 ~0. 92). The SROC area under curve (AUC) was for 0. 9517. n CONCLUSION:OCT for diagnosis of primary glaucoma has higher sensitivity and specific degree, has great value in clinical application.%目的：通过循证医学理论指导,应用多种评价指标和统计分析模型,分析光学相干断层扫描( optical coherence tomography,OCT)诊断原发性青光眼的能力,为临床医生诊断青光眼合理选用诊断方法提供参考依据。n　　方法：按照Cochrane 系统评价的方法,应用计算机检索PubMed、Web of Science、超星Medalink、CNKI数据库、中国生物医学文献数据库、万方数据库。收集所有OCT相关的诊断性试验,应用QUADAS质量评价标准对纳入研究进行质量评估后,采用Meta-Disc分析软件进行Meta分析。n　　结果：共纳入16个研究, Meta分析结果显示其合并敏感度、特异度及95%CI 分别为0.86(0.84~0.88)、0.90(0.88~0.92)。其SROC的曲线下面积(AUC)为0.9517。结论：OCT对原发性青光眼诊断有较高敏感度和特异度,具有很好的临床应用价值。