MMP-9与糖尿病视网膜病变患者血清中果糖胺的关联性

摘要

目的：探讨糖尿病视网膜病变患者血清中MMP-9的表达水平与血清果糖胺( Fructosamine,FRU)相关性,进一步明确MMP-9在糖尿病视网膜病变中的作用。　　方法：选择30例糖尿病视网病变患者和30例健康体检者,检测血清中的果糖胺,并运用采用酶联免疫吸附试验检测血清MMP-9表达水平。　　结果：与健康对照组(2.47依1.41pmol/L)比较,糖尿病视网膜病变患者血清中 MMP-9的表达水平(8.14依2.28pmol/L)明显升高(P<0.05)；MMP-9水平与血清中的果糖胺表达水平呈现正相关(r=0.94,P<0.05)。　　结论：糖尿病视网膜病变的发生与发展可能与 MMP-9表达水平密切相关,MMP-9在糖尿病视网膜病患者血清中的异常表达可能与果糖胺的分泌相关。%AIM:To explore the relationship of MMP-9 and serum fructosamine levels and further illustrate the role of the development in diabetic retinopathy patients. METHODS: Serum MMP - 9 levels were measured using enzyme - linkedimmunosorbent assays a in 30 health controls and 30 diabetic retinopathy patients, the relationship of MMP-9 and serum fructosamine levels were analyzed. RESULTS: Compared with healthy controls. The expression levels of MMP - 9 indiabetic retinopathy patients were significantly increased [(8. 14±2. 28pmol/L), vs ( 2. 47 ± 1. 41pmol/L )], MMP - 9 were positive correlation with fructosamine (r=0. 94, P<0. 05). CONCLUSION:The occurrence and progress of diabetic retinopathy might be closely related to the expression level of MMP-9, and the abnormal expression of MMP-9 in patients'serum might be associated with the secretion of fructosamine.