角膜层间灼烙联合羊膜移植治疗疼痛性大泡性角膜病变

摘要

目的：：观察角膜层间灼烙联合羊膜移植治疗疼痛性大泡性角膜病变的手术疗效。方法：选取疼痛性大泡性角膜病( PBK )患者156例156眼(均为单眼),行角膜层间灼烙联合羊膜移植术,术后随访2~3mo,观察患者术眼疼痛症状、角膜上皮水泡、异物感、术后并发症等指标。结果：疼痛症状全部消失,角膜上皮不再出现水泡130例(83.3%)；患者剧烈眼疼消失,但偶有异物感等不适,角膜上皮偶有小水泡24例(15.4%)；术后2wk内角膜基质发生溶解,再行结膜瓣覆盖后治愈2例(1.3%)。结论：角膜层间灼烙联合羊膜移植术能解除98.7%的PBK患者的痛苦且手术操作简单,值得提倡。%AlM:To evaluate the effect of intralamellar cryolysis of cornea with amniotic membrane transplantation on painful bullous keratopathy ( PBK) .•METHODS: Randomly selected 156 cases ( 156 eyes ) with PBK who underwent surgery of intralamellar cryolysis of cornea with amniotic membrane transplantation. Followed up with 2 ~ 3mo, the symptoms of eye pain, corneal epithelial blisters, foreign body sensation and postoperative complications were observed.•RESULTS:Pain symptoms disappeared in all patients, and corneal epithelial blisters disappeared in 130 cases (83. 3%). All agonizing pain symptoms disappeared, but patients had occasional foreign - body sensation, occasional corneal epithelial blisters in 24 cases ( 15. 4%) . Two weeks after surgery, corneal stroma dissolved, 2 cases ( 1. 3%) of them were cured by conjunctival flap cover.•CONCLUSlON:The operation of intralamellar cryolysis of cornea with amniotic membrane transplantation can relieve the pain in 98. 7% of PBK patients and simple therapy for treating PBK. Hence, it's be worth to advocate for relieve the pain of patients.