阻塞性睡眠呼吸暂停低通气综合征患者脉络膜厚度的变化

摘要

目的:分析阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者的脉络膜厚度的改变.方法:纳入17例初次诊断为OSAHS的患者和31例健康对照者.利用频域光相干断层扫描仪,采用增强深部成像技术,测量黄斑中心凹及距离中心凹上方、下方、鼻侧和颞侧各2mm部位的脉络膜厚度并进行统计学分析.结果:对照组和 OSAHS 组中心凹脉络膜厚度分别为323.58±58.63、316.82±46.43μm,差异无统计学意义(t=0.409,P=0.684).对照组和 OSAHS 组距中心凹上方2mm 脉络膜厚度分别为318.29 ± 56.89、314.29 ± 59.8μm,差异无统计学意义(t=0.229,P=0.820).对照组和OSAHS组距中心凹下方2mm 脉络膜厚度分别为308.42±54.95、291.65±55.37μm,差异无统计学意义(t=1.009,P=0.318).对照组和 OSAHS 组距中心凹颞侧2mm 脉络膜厚度分别为308.23 ± 54.62、302.76 ± 46.97μm,差异无统计学意义(t=0.347,P=0.730).对照组和OSAHS组距中心凹鼻侧2mm脉络膜厚度分别为266.23±58.10、277.12±63.99μm,差异无统计学意义(t=-0.599,P=0.552).分别按睡眠呼吸暂停低通气指数和血氧浓度对OSAHS进行严重程度分级后比较,组内差异均无统计学意义(P>0.05).结论:与正常人相比,OSAHS患者的脉络膜厚度略有下降(中心凹鼻侧2mm除外),但差异无统计学意义.对于初次诊断为OSAHS的患者,疾病严重程度对脉络膜厚度无影响.%·AIM:To analyze the choroidal thickness alteration in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). ·METHODS: Seventeen patients who were diagnosed with OSAHS initially and 31 healthy individuals were enrolled. Enhanced depth imaging choriodal scans were obtained by spectral - domain optical coherence tomography. Choroidal thickness of subfovea, 2mm superior,inferior,nasal and temporal to the fovea were measured and statistically analyzed. ·RESULTS:Subfoveal choroidal thickness of the control group and the OSAHS group was 323.58 ± 58.63μ m and 316.82 ± 46. 43μ m respectively, and the difference was unsignificant(t=0.409,P=0.684). Choroidal thickness at 2mm superior to the fovea of the control group and the OSAHS group was 318.29 ± 56.89μ m and 314.29 ± 59.8μ m respectively, and the difference was unsignificant (t=0.229,P=0.820). Choroidal thickness at 2mm inferior to the fovea of the control group and the OSAHS group was 308.42± 54.95μ m and 291.65 ± 55.37μ m respectively, and the difference was not significant (t=1.009, P=0.318). Choroidal thickness at 2mm temporal to the fovea of the control group and the OSAHS group was 308. 23 ± 54.62μ m and 302. 76 ± 46. 97μ m respectively, and the difference was not significant (t = 0. 347, P = 0. 730). Choroidal thickness at 2mm nasal to the fovea of the control group and the OSAHS group was 266. 23 ± 58.10μ m and 277. 12 ± 63. 99μ m respectively, and the difference was not significant (t= -0.599, P= 0.552). There were no significant differences among subgroups after grading based on the severity of sleep apnea hypopnea index and blood oxygen concentration. ·CONCLUSION: Compared with healthy individuals, choroidal thickness of patients with OSAHS decreases slightly (except for the location of 2mm nasal to the fovea),but the alteration is not significant. The severity of OSAHS has no effect on the choroidal thickness for the patients first diagnosis of OSAHS.