丹参川芎嗪注射液对尿酸性肾病患者肾功能及肾血流影响研究

摘要

目的 观察丹参川芎嗪注射液对尿酸性肾病患者血尿酸、肾功能、肾形态、肾血流的影响.方法 选取尿酸性肾病患者64例,采用随机数字表法分为对照组和观察组,每组32例.对照组患者常规使用别嘌呤醇或苯溴马隆降尿酸治疗;观察组患者在此基础上加用丹参川芎嗪注射液治疗,两组患者均治疗42天.检测比较两组患者的血尿酸(UA)、血肌酐(Scr)、尿素氮(BUN)、尿β2-微球蛋白(β2-MG)水平;用彩色多普勒超声检测比较两组患者肾形态和肾主动脉(MRA)、肾段动脉(SRA)、叶间动脉(IRA)的血流情况.结果 疗程结束后,两组患者血UA、Scr、BUN、β2-MG水平均显著降低(P<0.05),观察组患者显著低于对照组(P<0.05);观察组患者MRA、SRA、IRA中段的Vsmax、Vdmin明显提高、RI明显降低(P<0.05),观察组患者Vsmax、Vdmin显著高于对照组、RI显著低于对照组(P>0.05);观察组患者治疗总有效率(81.25%)显著高于对照组(56.25%),临床疗效显著优于对照组(P<0.05).结论 在常规使用别嘌呤醇或苯溴马隆降尿酸治疗的基础上,加用丹参川芎嗪注射液治疗尿酸性肾病患者,可显著改善患者肾血流状态,延缓肾间质纤维化进程,降低尿蛋白水平,改善肾功能,提高临床治疗效果.%Objective To observe the effect of danshen chuanxiongqin injection on serum uric acid, renal function, renal morphology and blood flow in patients with uric acid nephropathy.Methods A total of 64 patients with uric acid nephropathy were randomly divided into control group and observation group, with 32 cases in each group.The control group received routine treatment of decreasing trioxypurine, the drug was allopurinol or benzbromarone;while the observation group were treated with danshen chuanxiongqin injection on the basis of routine treatment, the course of treatment of two groups was 42 days.The uric acid (UA) ,serum creatinine (Scr), urea nitrogen (BUN) and urine β2-macroglobulin (β2-MG)of the two groups were detected, and the above indexes were compared between the two groups;and renal morphology, the blood flow of renal artery (MRA), renal artery (SRA), interlobar artery (IRA) were detected by color doppler ultrasound.Results After three courses of treatment, the blood UA, Scr, BUN, β2-MG of the two groups decreased significantly (P<0.05), and the decreased in the observation group was more significant (P<0.05);the Vsmax and Vdmin of MRA, SRA, IRA in the observation group were significantly increased compared with those before treatment, and significantly higher than those in the control group (P<0.05), the RI of MRA, SRA, IRA in the observation group were significantly decreased compared with those before treatment, and significantly lower than those in the control group (P<0.05);the total efficiency of the observation group (81.25%) was significantly higher than that in the control group (56.25%, P<0.05), and the curative effect in the observation group was significantly superior to that in the control group (P<0.05).Conclusions On the basis of allopurinol or benzbromarone, danshen chuanxiongqin injection in the treatment of uric acid nephropathy, can improve the blood flow status, delay the process of renal interstitial fibrosis, reduce proteinuria, improve renal function and clinical efficacy.