治疗耐药细菌感染的抗菌药物研究进展

摘要

细菌耐药是感染性疾病治疗面临的主要挑战,临床可用的针对耐药细菌的抗生素较为稀少,抗菌药物的研究与开发主要在三个方面:①通过结构修饰,继续对已有抗菌药物进行深入开发,获得了一些新产品;②对临床应用的药物进行重新评估,制订更有效的用药方案;③利用基础科学研究成果,寻找新的抗菌靶位,设计新的先导化合物,研究全新抗菌药物.这些有望为控制耐药菌感染提供有效方法.%Antimicrobial resistance is the major challenge for the treatment of infectious diseases. Few effective antibiotics are available for clinical practice. Antibiotic research and development provide means for containment of bacterial resistance in 3 aspects: ①developing new antibacterial agents by molecular modification of available antimicrobial agents; ②re-evaluating the antibiotics in use and optimizing therapeutic regimens for drug-resistant bacterial infections; ③exploring new antibacterial targets and designing new compounds with antibacterial activity against resistant germs by taking the advantage of the achievements in basic researches.All the efforts are expected to contribute to the control of drug-resistant bacterial infections.