埃博拉病毒病疫苗研究进展

摘要

Ebola virus disease (EVD), caused by Ebola virus (EBOV), is a severe hemorrhagic contagious disease. Since March 2014, it has spread in several countries of West Africa, which have captivated the world's attention and concern, and WHO declared the EVD outbreak in West Africa as a public health emergency of international concern. Though several impeding factors have limited the development of Ebola vaccines and there are no approved Ebola vaccines for humans, the current epidemic has provided a surge for faster development of Ebola vaccines. This article focuses on the advances in the development of Ebola vaccines, including animal mo-dels for vaccine evaluation, types of Ebola vaccines and clinical studies of experimental vaccines.%埃博拉病毒病(Ebola virus disease, EVD)是由埃博拉病毒引起的一种急性出血性传染病. 自2014年3月以来, EVD在西非多个国家暴发,引起全球关注,WHO已将此疫情列为国际关注的突发公共卫生事件.虽然有很多因素限制了EVD疫苗的发展,目前无可用于人的疫苗获批上市,但当前的严峻形式促进了疫苗研究的发展. 本文着重介绍EVD疫苗相关的研究进展,包括评价疫苗所用的动物模型、疫苗种类和进入临床试验的疫苗.