肝纤维化血清学检测指标的研究进展

摘要

Liver fibrosis is the pathological process of abnormal proliferation of fibrous connective tissue in the liver when the liver cells undergo necrosis and inflammatory stimulation. It is an important intermediate link in the development of chronic liver diseases. At present, the gold standard for diagnosis of liver fibrosis is still the pathological biopsy, but it has many shortcomings and insufficiency, which makes it difficult to be widely carried out in clinical practice. The related serological detection index is simple and rapid, and has less trauma, especially suitable for the patients who cannot receive live puncture. This review focuses on the research progress of serological detection index in the liver fibrosis diagnosis.%肝纤维化是肝细胞发生坏死及炎症刺激时，肝脏内纤维结缔组织异常增生的病理过程，而且是慢性肝病发展为肝硬化的重要中间环节。目前，肝纤维化诊断的金标准仍然是病理组织活检，但其有很多缺点和不足，难以在临床广泛开展。血清学相关检测指标简便快速，创伤小，尤其适用于不能进行肝脏穿刺的患者。现就血清学检测指标在肝纤维化诊断中的进展作一综述。