Research progress on the relationship between high-risk HPV infection and urinary system tumor

摘要

Human papillomavirus (HPV) is classified either as high-risk or low-risk types depending on its probability of leading to tumorigenesis. Many studies have shown that HPV infection, especially the high-risk kind, is always related to prostate cancer, bladder cancer, penile cancer, testicular cancer, and other urinary system tumors. However, previous studies differed in sexual openness and racial genetic susceptibility of the study object, sample size, and experimental methods.Hence, the correlation between high-risk HPV infection and urinary system tumors remains controversial. The early open reading frame of the HPV genome is composed of E1-E7, among which E6 and E7 are the key transfer proteins. The combination of these proteins with oncogene and anti-oncogene may be one of the mechanisms leading to tumorigenesis.