基于能量转移机理的水溶性荧光共轭聚合物体系的设计制备及应用

摘要

水溶性共轭聚合物由于具有优异的光学性能,如强大的光捕获能力和独特的分子线效应,在化学、生物和医疗领域都有良好的应用前景.共轭聚合物受光激发后,所产生的激子可以沿着长程共轭的π骨架自由迁移,在分子骨架的任何位点都可以转移给能量受体,从而实现高效的能量传递.因此,水溶性共轭聚合物适合于构建各种能量传递体系,从而实现荧光信号放大、多色发光、活性氧产生效率提高等光学性能的优化.本文简述了基于水溶性共轭聚合物构建能量转移体系的原理和方法,总结了其在生物传感、生物成像、光动力杀菌和光动力抗癌等领域的应用,最后对水溶性共轭聚合物存在的主要问题以及未来的发展方向进行了分析和展望.%Water-soluble conjugated polymers have promising applications in chemical,biological and medical fields,due to its excellent photoproperties like strong light harvesting ability and unique molecular wire effect.Upon irradiation,the exciton generated can migrate freely along the whole πr-conjugated backbone and transfer energy to the acceptor at any backbone site,leading to high energy transfer efficiency.Therefore,the conjugated polymers are especially suitable to construct energy transfer system which can provide enhanced fluorescence signals,multi-color emission and improved efficiency on reactive oxygen species generation.In this review,we summary the principle and strategy of developing the energy transfer systems using water-soluble conjugated polymers,and their applications in biological sensing,imaging,photodynamic therapy and antibacterial.Finally,the future opportunities and challenges of WSCPs are discussed.