乙酰氨基阿维菌素原位凝胶注射剂体外释放度测定方法研究

摘要

The purpose of this study was to determine the release of in situ gel injection of Eprinomectin in vitro (EPR﹚. The vitro release of EPR in situ gel injection was measured by high performance liquid chromatography (HPLC﹚ using PBS buffer as a release medium. The results showed that it is feasible to determine the vitro release of EPR in situ gel injection by HPLC and the vitro release curve showed that EPR in situ gel injection had the characteristics of sustained release. This conclusion was that the HPLC method was suitable for the vitro release of EPR in situ gel injection with pH 7.4 PBS buffer solution as a release medium.%研究乙酰氨基阿维菌素(Eprinomectin,EPR)原位凝胶注射剂体外释放度的测定方法,采用高效液相色谱法(High performance liquid chromatography,HPLC)测定EPR原位凝胶注射剂的体外释放度° 结果表明,采用HPLC测定EPR原位凝胶注射剂体外释放度方法是可行的,体外释放曲线表明EPR原位凝胶注射剂有缓释的特点°以pH 7.4的PBS缓冲溶液作为释放介质的HPLC适用于EPR原位凝胶注射剂体外释放度的测定.