PPARγ 在脂肪生成中的遗传和表观遗传调控

摘要

过氧化物酶体增殖物激活受体 γ(peroxisome proliferator-activated receptor gamma,PPARγ)是脂肪生成和脂肪组织发育的关键调控因子,另外在糖脂代谢、炎症和免疫反应等多种生物学过程中也发挥重要作用.近年来,对PPARγ 基因的研究一直是脂肪生物学研究的热点.随着研究的不断深入,人们发现PPARγ 基因不仅受遗传调控,还受DNA甲基化、组蛋白修饰、非编码RNA和染色质重塑等表观遗传调控.本文综述了PPARγ基因在脂肪生成中的遗传和表观遗传调控研究进展,探讨了未来PPARγ 基因调控的研究方向和趋势.%Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis and adipose tissue development. It also plays crucial roles in many other biological processes, including lipid and glucose metabolism and energy homeostasis. Recently, evidence has been accumulating that the PPARγ gene is not only ge-netically regulated, but also epigenetically regulated by DNA methylation, histone modification, non-coding RNA and chromosome remodeling. In this review, we summarize the advances in the genetic and epigenetic regulation of the PPARγ gene during adipogenesis, and discuss future research directions and trends for the study of its regulation.