目的 观察卡泊三醇软膏与糠酸莫米松乳膏联合治疗寻常型银屑病的疗效和安全性.方法 将180例银屑病患者随机分为3组各60例,A组给予糠酸莫米松乳膏外用,qd;B组给予卡泊三醇软膏外用,bid;C组给予糠酸莫米松乳膏外用,qd,加用卡泊三醇软膏外用,bid.疗程均为4周,随访3个月,观察临床疗效、安全性和复发率.结果 治疗4周后,A、B、C组临床治愈率分别为30.0%,33.3%,56.7%(P＜0.05);显效率分别为43.3%,46.7%,33.3%(P＜0.05);有效率分别为73.3%,80.0%,90.0%(P＜0.05);随访3个月后,B组和C组的临床复发率显著低于A组(P＜0.05).3组患者均无严重不良反应.结论 卡泊三醇软膏与糠酸莫米松乳膏联合治疗寻常型银屑病安全,有效.%Objective To study the effect of treating proriasis vulgaris with calcipotriol ointment plus mometasone furoate cream. Methods 180 patients with proriasis vulgaris were randomly divided into three treatment groups,group A ( 60 cases ) were treated with mometasone furoate cream, group B ( 60 cases ) were treated with calcipotriol ointment, and group C ( 60 cases ) were treated with calcipotriol ointment and mometasone furoate cream, the duration of treatment was 4-week and follow-up was 3-month. The therapeutic effect, safety and recurrence were recorded. Results The curative rates of three ways were 30.0% ( group A ), 33.3%( group B ) and 56. 7% (groupC), the efficiency were 43. 3% ( groupA), 46.7%( group B ),and 33. 3%( group C ), the efficacy were 73. 3%( group A ),80.0%( group B ),and 90.0%( group C ), respectively ( P< 0. 05 ). The recurrence of group B and group C were significantly lower than that of group A. All cases were safe during process of treatment. Conclusion Combination of calcipotriol ointment and mometasone furoate cream is effective and safe for the treatment of psoriasis vulgaris.
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