2004～2009年我国药品不良反应文献源统计分析

摘要

目的 了解国内近年文献中对药物不良反应的研究状况,全面回顾前人的研究方法,寻找其中存在的问题,探索更好的研究方向和研究方法.方法 对中国期刊网2004～2009年间报道的药物不良反应文献进行统计分析,然后进行多方面、多方向的对比研究.结果 目前对药物不良反应的研究方法仅关注药物不良反应发生的频次;从频次上看,化学药不良反应报道文献较多,化学药中抗微生物药、中枢神经系统药物、循环系统药物、抗肿瘤药物不良反应报道文献较多,它们对机体的影响涉及机体各个系统器官,有些会出现严重药物不良反应.结论 应加强药物的合理使用及不良反应监测,为临床用药提供更充分、实际的参考资料,以减少和避免药物不良反应的发生.%Objective To investigate recent researches on adverse drug reaction ( ADR ) in literatures, and a comprehensive review of previous studies, find problems inside and explore a better research methodologies. Methods Statistical analysis of online journals for adverse drug reactions reported in China between 2004 to 2009 was carried out, and various multi-dimensional comparation was studied. Results Current researches on adverse drug reactions are only concerned with the frequency of occurrence; from the frequency, the chemical drugs derived adverse reactions have been more reported, most of which are the anti-microbial drugs, drugs on central nervous system, on circulatory system, anti-neoplastic agents. The side effects of which are involved in the various organs, and some are serious. Conclusion The rational use of medicines should be enforced and provide more adequate and practical reference for clinical medication, in order to reduce and prevent the occurrence of ADR.