Objective To investigate the application of fluoroquinolone and provide the evidence for rational use of medicines. Methods The number and cost of fluoroquinolone consumed in 24 hospitals of Wuhan from 2008-2010, frequency of drug use (DDDs) and average daily costs (DDC) were analyzed statistically. Results During three years, the annual sales of fluoroquinolone were around 110-120 million, in which the injection occupied around 83%-84%. Levofloxacin, gatifloxacin, pazufloxacin, moxifloxacin, enoxacin had been ranked as the top five in sales, in which levofloxacin was the highest DDDs. Conclusion With the expanding use of fluoroquinolone, drug resistance becomes more seriously. The rational use and related index of drug economics of fluoroquinolone need further evaluating.%目的 了解喹诺酮类药物使用情况,为合理用药提供依据.方法 对武汉市24家医院2008 ～ 2010年喹诺酮类药物使用数量、消耗金额、用药频度(DDDs)和日均费用(DDC)进行统计分析.结果 3年中喹诺酮类药年销售金额11 000～12000万元,注射剂占总年销售额的83％ ～ 84％,销售金额前5位的药物均为左氧氟沙星、加替沙星、帕珠沙星、莫西沙星、依诺沙星,其中左氧氟沙星用药频度最高.结论 随着喹诺酮类抗菌药物使用量的增大,耐药问题日益严重,使用的合理性及药物经济学等相关指标有待进一步深入评价.
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