安神补眠颗粒喷雾干燥工艺∗

摘要

Objective To optimize spray drying process of Anshen bumian granules. Methods By using orthogonal design method, moisture content, powder rate and berberine hydrochloride content were indexes, and optimum technological conditions were determined. Results Proportion of microcrystalline cellulose, lactose and maltodextrin was 2��1��2. The extract was fed in at 6%. Optimum feeding in/out temperature for spray drying is 145 ℃ /85 ℃, liquid velocity was 30 mL��min-1 , and relative density of extract was 1. 15. Conclusion The process is reasonable and practical, has strong stability and good controllability, and it provides a basis for industrialized production.%目的：对安神补眠颗粒的喷雾干燥工艺进行优化。方法采用正交设计法，以含水率、得粉率和盐酸小檗碱的含量作为指标，确定最佳工艺条件。结果选取微晶纤维素、乳糖、麦芽糊精三种辅料以2��1��2的比例，按照浸膏6％投料，喷雾干燥最佳工艺参数为进/出温度为145℃/85℃，进液速度为30 mL��min－1，浸膏相对密度为1.15。结论该工艺合理可行，稳定性强，可控性好，为工业化生产提供依据。