冬凌草甲素-单壁碳纳米管载药体系的制备及其吸附动力学

摘要

Objective To investigate the method for preparing oridonin-single-walled carbon nanotubes ( ORI-SWCNTs) nanocomposite and study its adsorption kinetics. Methods ORI-SWCNTs nanocomposite was prepared by using the method of solution mixing. The synthesized ORI-SWCNTs nanocomposite was characterized by using Laser particle size analyzer, Fourier transform infrared, DSC analysis, powder X-ray diffraction and electron microscopy techniques. Results The encapsulation efficiency and loading capacity of ORI in SWCNTs-COOH nanocarrier was estimated to be about (70.23±2.1) %and (27.29±1.2) %, respectively. The Zeta potential was (-34.29±1.2) mV, partical size was about (458±18) nm. The absorption of ORI on SWCNTs-COOH could be explained by pseudo-second-order model. Conclusion The established preparation process of ORI-SWCNTs nanocomposite by solution mixing is feasible, with higher loading efficiency and encapsulate efficiency..%目的 探讨冬凌草甲素-单壁碳纳米管载药体系的制备方法及其吸附动力学特征.方法 采用溶液共混法制备冬凌草甲素-单壁碳纳米管载药系统,并用激光粒径仪、电镜、红外光谱、差示扫描量热仪(DSC)、X射线衍射等对其进行表征,进行吸附动力学的研究.结果 冬凌草甲素-单壁碳纳米管载药体系的包封率为(70.23±2.1)%,载药量为(27.29±1.2)%,Zeta电位为(-34.29±1.2)mV,平均粒径为(458±18)nm,冬凌草甲素在羧基化单壁碳纳米管(SWCNTs-COOH)表面的吸附符合准二级动力学吸附模式.结论 冬凌草甲素-单壁碳纳米管载药体系制备工艺简单,储存稳定性好,载药量和包封率高.