翻转静脉与常规静脉用于桥接修复周围神经缺损的比较研究

摘要

Objective： In order to provide a new method to repair peripheral nerve defect,this article detected the influence on nerve regenerating,when using inside-out vein grafts to bridge the gap in peripheral nerve.Methods: Turn the harvested vein segments inside-out，then,repair the sciatic nerve defect with them(IOVG),and compare their results with convential vein graft(CVG).By 5 months postoperatively,the quantitative analysis in histology and the nerve electrophysiological test were performed.Results: The number,the mylin sheath thickness and the conduction velocity of the regenerating fibers had been improved in IOVG.Conclusion： Bridging a defect in peripheral nerve with inside-out vein graft is a simpler and more effective method.%目的： 探寻静脉翻转后对引导神经再生的影响，为周围神经缺损的修复提供一种新方法。方法： SD大鼠静脉段取出后，先将其内外翻转成一外膜在内，内膜在外的翻转静脉。然后再用此翻转静脉段桥接修复大鼠自体坐骨神经10 mm缺损(IOVG)并与常规静脉桥接修复方法(CVG)进行对比研究。术后5个月，进行神经电生理及组织形态学检测。结果： 与CVG相比，IOVG组再生神经纤维的数目、髓鞘厚度、纤维直径以及运动神经传导速度均有提高。结论： 翻转静脉桥接修复周围神经缺损是一简单而有效的新方法。