支气管哮喘患儿治疗前后血清SOD、VIP、TNF-α和Lep水平变化的临床意义

摘要

Objective:To explore the clinical significance of determining Changes of serum SOD、VIP、TNF-αand Lep levels in before and after therapy in pediatric patients with Bronchial asthma. Methods:the serum SOD、VIP、TNF-αand Lep levels were de-termined in 87 pediatrics patients with bronchial asthma and 60 controls by radioimmunoassay and enzyme immunoassay as well as done study compared. Results:In before therapy, the serum SOD and VIP levels in 87 pediatrics patients with bronchial asthma were significantly lower than in those of to controls(tSOD=3.018,tVIP=3.146,Pall<0.01),the serum TNF-αand Lep levels in 87 pediatrics patients with bronchial asthma significantly higher than in those of 60 controls(tTNF-α=4.637,P<0.001,tLep=3.261,P<0.01). In af-ter therapy, the serum SOD and VIP levels in 87 pediatrics patients with bronchial asthma were discovery to normal levels and not much different than in those of 60 controls(tSOD=1.586,tVIP=1.563,Pall>0.05),but the serum TNF-αand Lep levels were signifi-cantly decreased and still higher than in those of 60 controls(tTNF-α=2.103,tLep=2.243,Pall<0.05). Conclusion:The serum SOD and VIP levels were a valueable index for diagnosis of pediatrics patients with bronchial asthma and after inhalation of Glucocorticoi-ols therapy, could be following and test effect of therapy.%目的：为了探讨支气管哮喘患儿治疗前后血清SOD、VIP、TNF-α和Lep水平变化的临床意义。方法：放射免疫分析和酶免疫分析测定了87例支气管哮喘患儿和60例正常儿的血清SOD、VIP、TNF-α和Lep水平并进行了比较性分析。结果：在治疗前，87例支气管哮喘患儿血清SOD和VIP水平较之60例正常儿明显降低（tSOD=3.018，tVIP=3.146，P均<0.01），而血清TNF-α和Lep水平明显增高（tTNF-α=4.637，P<0.001，tLep=3.261，P<0.01）。在治疗后，87例支气管哮喘患儿血清SOD和VIP水平恢复至正常，较之正常儿无明显的差异（tSOD=1.586，tVIP=1.563，P均>0.05），而血清TNF-α和Lep水平明显降低，但相较之正常儿增高（tTNF-α=2.103，tLep=2.243，Pall<0.05）。结论：SOD和VIP水平的测定是诊断支气管哮喘患儿的良好指标，而且在糖皮质激素综合治疗后，可以进行随访和疗效的考核。