基因芯片技术在诊断微生物学中的研究进展及应用

摘要

近年来，基因芯片技术发展迅速，已广泛应用于多种领域，被视为一次意义深远的现代科技革命。通过总结基因芯片制备技术及其在诊断微生物学的应用进展，分析目前在临床应用中存在的问题和不足，指出基因序列信息缺乏和专利限制等因素是制约该技术发展和应用的瓶颈，为未来基因芯片技术的发展提供参考和借鉴。%In recent years ,gene chip technology had rapidly developed and also been widely applied ,therefore it was regarded as a revolution in science and technology .The application of gene chip in pathogenic microorgan‐ism‐caused diseases diagnosis had been made the breakthrough as well ,and it would become an effective techni‐cal means in some complex diagnosis and treatment .The development of the gene chip and its application in the diagnosis of microbiology were reviewed ,and the problems in clinic application were pointed out .The results concluded that the lack of genome sequence and the patent issues were the main limit factors in the technique development as a suggestion for the future improvement .