还原性谷胱甘肽治疗酒精性肝硬化60例临床观察

摘要

Objective: To observe the therapeutic efficacy of reduced glutathione for patients with alcoholic cirrhosis. Method: One hundred and twenty patients with alcoholic cirrhosis were randomly divided into two groups. The control group received routine therapy alone , while the trial group received reduced glutathione injection ( 1.2g ) q. d plus routine therapy for 2 weeks. Then observed the changes of symptoms and signs, hepatic function and hepatic fibrosis. Result: The improvement in symptoms and signs , the hepatic function and hepatic fibrosis in the trial group was significant superior to those in the control group, There's significant differences between the two groups( P<0.01 ). Conclusion: Reduced glutathione has remarkable therapeutic efficacy for patients with alcoholic cirrhosis , it can distinctly improve the hepatic functions and inhibit liver fibrosis.%目的:观察还原型谷胱甘肽治疗酒精性肝硬化的临床疗效.方法:120例酒精性肝硬化患者,随机等分为治疗组(60例)和对照组(60例).对照组采用常规治疗,治疗组在此基础上给予还原型谷胱甘肽1.2g静脉滴注,每日1次,共治疗2wk.观察两组临床疗效并检测治疗前后肝功及肝纤维化指标的变化.结果:治疗组在改善患者症状、体征及降低肝功能、肝纤维化指标方面均明显优于对照组,两组差异有显著性意义(P<0.01).结论:还原型谷胱甘肽对酒精性肝硬化有良好的治疗作用,可显著改善肝功能,抑制肝纤维化.