Objective: To explore the effects of gastroesophageal reflux disease treated by rabeprazole and mosapride. Method: 150 patients of gastroesophageal reflux disease from Mar. 2005 to Mar. 2011 were randomly divided into two groups, the observation group(n = 74) ,and the control group(n = 76). The observation group were given rabeprazole and mosapride, and the control group were treated only with rabeprazole. Result: After two months treatment, the total effective rate in the observation group was 93. 24% .significantly difference to the control group ,with the rate of 81. 58% ( X2 =4.61 ,P＜0.05). There was no obvious adverse effect. Conclusion: The treatment effect of gastroesophageal reflux disease treated by rabeprazole and mosapride would be remarkable, safe and reliable, which could apply in practice.%目的:探讨雷贝拉唑、莫沙必利联合治疗胃食管反流的临床疗效.方法:将2005年3月至2011年3月于我院诊治的胃食管反流病150例随机分成观察组74例、对照组76例.对照组应用雷贝拉唑治疗,观察组在其基础上加用莫沙必利治疗.结果:治疗2个月后,观察组总有效93.24％；对照组总有效率81.58％.观察组总有效率明显高于对照组,差异有统计学显著性(X2 =4.61,P＜0.05).两组均无明显不良反应.结论:雷贝拉唑、莫沙必利联合治疗胃食管反流病临床疗效显著,应用安全,可于临床推广.
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