CT灌注成像在脑胶质瘤诊断中的应用价值

摘要

Objective: To investigate the value of CT perfusion imaging in the diagnosis of glioma. Method: Selected 50 cases of glioma patients inspected in the hospital imaging center from March 2010 to July 2011, All patients underwent CT perfusion scanning, reconstruction of CT perfusion images to measure the ROI of cerebral blood flow ( CBF ), cerebral blood volume ( CBV ), mean transit time ( MTT ), and measure the microvessel density in pathologic specimens. Result: The mean value of CBF, CBV and PS were significantly higher in high-grade gliomas group than the group of low-grade gliomas, and the differences were statistically significant ( P 〈0. 01 ). Group of high-grade gliomas and low-grade gliomas group MTT had no significant difference between the mean value ( P〉 0. 05 ). Through spearman correlation analysis, the glioma CT perfusion rCBV values with MVD has a significant positive correlation ( r = 0. 571, P〈0. 05 ). Conclusion: The high-grade gliomas and low-grade gliomas CT perfusion imaging parameters has significant differences,There's a significant positive correlation between rCBV and MVD.%目的:探讨CT灌注成像在脑胶质瘤诊断中的应用价值.方法:选择2010年3月至2011年7月间我院及重庆医科大学附属第一医院影像中心检查的脑胶质瘤患者50例,所有患者均行CT灌注扫描,于重建的CT灌注图像上测量各ROI的脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTT),并测量病理标本中的微血管密度.结果:高级别胶质瘤组CBF均值、CBV均值及PS均值均显著高于低级别胶质瘤组,其差异均有统计学意义(P＜0.01).高级别胶质瘤组与低级别胶质瘤组MTT均值间无统计学差异(P＞0.05).经Spearman相关分析,胶质瘤CT灌注rCBV值与MVD间具有显著正相关性(r=0.571,P<0.05).结论:高级别胶质瘤与低级别胶质瘤CT灌注成像参数存在明显差异,且rCBV值与MVD间具有显著正相关性.