血清 sTWEAK 与冠心病严重程度的关系及其对急性心肌梗死发病的预测价值

摘要

Objective:To investigate the relationship between human soluble tumor necrosis factor-like apoptosis weak inducible factor ( sTWEAK ) with severity of coronary heart disease and its predictive value for acute myocardial infarction ( AMI). Method:176 cases with CHD in our hospital, including 98 patients with unstable angina pectoris ( UAP group ), 18 patients with stable angina pectoris ( SAP group ), 60 pa-tients with acute myocardial infarction ( AMI group ) and 36 cases in normal control group. The sTWEAK concentration was measured by sTWEAK ELISA and the assessment of the severity of CHD were used by cor -onary angiography Gensini score method. Result:sTWEAK concentration of 60 patients with AMI were sig-nificantly higher than the other patients, the difference was statistically significant ( P<0.05); the clinical actual concentration of sTWEAK had positively correlated with Gensini scores, and it can be regarded as one of the factors for high-risk of AMI, the difference was statistically significant (P<0.05).Conclusion: For the patients with acute myocardial infarction, the serum sTWEAK concentration level is higher than the non-AMI patients and the control group patients, Therefore, sTWEAK is regarded as a risk factor for the onset of AMI and its positive correlation with CHD severity.%目的：探讨分析人可溶性肿瘤坏死因子样凋亡弱诱导因子（ sTWEAK ）与冠心病（ CHD ）严重程度的关系及其对急性心肌梗死（ AMI）发病的预测价值。方法：对在本院住院治疗的176例冠心病患者随机分组，其中包括不稳定性心绞痛（ UAP ）组患者98例、稳定性心绞痛（ SAP ）组患者18例、急性心肌梗死（ AMI）组患者60例，同时选取无冠心病史的36例患者为对照组。采用sTWEAK ELISA 试剂盒对血sTWEAK的浓度进行测定，CHD 严重程度的评估采用冠状动脉造影Gensini 评分方法。结果：60例AMI患者临床监测的sTWEAK的浓度明显高于其他患者，差异有统计学意义（ P＜0．05）；监测到的sTWEAK临床实际浓度与Gensini评分呈正相关，可将其视为AMI的高危因素之一，差异有统计学意义（ P＜0．05）。结论：对于急性心肌梗死患者而言，血清sTWEAK 的浓度水平高于非AMI患者以及对照组患者，故在临床中可将sTWEAK 视为AMI 发生的危险因素且其与CHD 严重程度正相关。