Objective:To explore the correlation between coagulation indicator and clinical pathological characters in patients with cervical cancer , so to provide reference for diagnosis of clinical cervical cancer . Method:118 cases with cervical lesions treated in our hospital from 2009 , Jan to 2013 , Dec were retrospec-tively analyzed , including three types of normal cervix uteri , cervical intraepithelial neoplasia ( CIN ) and cervical cancer according to histopathology classification .At the same time, the cervical cancer was divided into termⅠtoⅡand termⅢto Ⅳ two different stages based on FIGO tumor staging criteria , and the lym-phatic metastasis was confirmed as well .Each aspect of coagulation indicator was collected using fully auto-matic blood coagulation analyzer of ACL-TOP and blood platelet indicator was collected using fully automatic blood cell analyzer of Sysmex 3000 in all patients with cervical lesions .Difference of coagulation indicator in-cluding prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fi-brinogen ( Fib) , D-dimer positive rate and platelets ( PLT) concentration were made among different tumor types, different stages and groups with lymph node metastasis or not .Result: Compared to normal cervix uteri, the level of PT and D-dimer positive rate were significantly higher in CIN ( P<0.05) and the level of PT, APTT, Fib and D-dimer positive rate were higher with significant difference (P<0.05).Compared to the stage ofⅠtoⅡ, the value of PT, APTT, Fib and D-dimer positive rate were significantly higher in termⅢto Ⅳ( P<0.05) ,while others showed no significance ( P>0.05) .Compared to non-lymphatic metastasis , the value of PT, APTT, Fib, PLT and D-dimer positive rate all were in high degree with significant differ-ence(P<0.05).Conclusion: Dysfunction of coagulation function always exists in cervical cancer patients , the detection of coagulation indicators in cervical cancer patients can assist the clinical staging diagnosis and the development of disease .%目的：探讨宫颈癌患者凝血指标与肿瘤临床病理特征的相关性，为临床病理诊断提供参考。方法：回顾性分析我院2009年1月至2013年12月收治的宫颈病变患者118例，其中根据宫颈癌病理演变过程分为正常宫颈，宫颈癌前病变（ CIN ）和宫颈癌三类，而根据FIGO肿瘤分期标准将宫颈癌又分为Ⅰ－Ⅱ期和Ⅲ－Ⅳ，同时检测淋巴结有无转移。对所有患者采用ACL－TOP 全自动血凝分析仪检测各项凝血指标和采用Sysmex3000型全自动血细胞分析仪检测血小板含量，比较不同病理类型，肿瘤不同分期以及有无淋巴结转移间的各项凝血指标包括血浆凝血酶原时间（ PT）、部分凝血活酶时间（ APTT）、凝血酶时间（ TT）、纤维蛋白原（ Fib）、D－二聚体阳性率和血小板（ PLT）的差异。结果：与正常宫颈相比，宫颈癌前病变（CIN）仅在PT和D－二聚体阳性率上表现有明显的统计学差异（P＜0．05），宫颈癌患者在PT，APTT，Fib和D－二聚体阳性率上均表现有明显的统计学差异（ P＜0．05）；与Ⅰ－Ⅱ期相比，Ⅲ－Ⅳ期的PT，APTT，Fib和D－二聚体阳性率均明显升高，差异均具有统计学意义（P＜0．05），而TT，PLT则差异不明显（ P＞0．05）；与无淋巴结转移的宫颈癌患者相比，伴有淋巴结转移的患者中PT， APTT，Fib，PLT值以及D－二聚体阳性率均明显升高，各项差异均具有统计学意义（ P＜0．05）。结论：宫颈癌患者常伴有凝血功能紊乱，检测患者体内的各项凝血指标可为宫颈癌的临床分期诊断和病情发展提供帮助。
展开▼
