RF AKA CRP CCP和ANA五项检测诊断类风湿性关节炎的临床意义

摘要

objective:To evaluated the clinical significance of combined Rheumatoid factor ( RF) , anti keratin antibodies ( AKA) , c-reactive protein ( CRP ) , Anti-cyclic citrullinated peptide antibody ( CCP ) and antinuclear antibody ( ANA) five detection in diagnosing rheumatoid arthritis. Methods:Detected 162 RA pa-tients and 50 cases of healthy physical examination for serum RF, AKA, CRP , anti-CCP antibody and ANA level, compared two groups of 5 indicators of positive proportion and evaluated the ability of indicators in the diagnosis of RA.Results:The observation group of RF, AKA, CRP, serum anti - CCP antibody, the ANA positive rate were significantly higher than control group ( P < 0.01 or P < 0.05);combined five indicators to detected specific degrees higher than single RF, CRP, ANA test (P < 0.05), higher than that of single RF sensitivity, AKA, CRP, anti -CCP antibody, ANA test (P < 0.05).Conclusion:Combined detection of ser-um levels of RF, AKA, CRP, anti -CCP antibody, ANA level can significantly improve the diagnosis sensi-tivity of RA,it is helpful to early diagnosis of RA.%目的：：评价联合检测类风湿因子( RF)、抗角蛋白抗体( AKA)、C反应蛋白( CRP )、抗环瓜氨酸(抗－CCP )抗体、抗核抗体( ANA)在诊断类风湿关节炎( RA)的临床意义。方法：检测162例RA患者和50例健康体检者的血清RF、AKA、CRP、抗－CCP 抗体和ANA水平，比较两组5项指标的阳性比例并评价5项指标诊断RA的能力。结果：观察组的血清RF、AKA、CRP、抗－CCP 抗体、ANA阳性比例均显著高于对照组( P 均<0.01或P<0.05)；联合检测5项指标的特异度高于单独RF、CRP、ANA检测( P 均<0.05)，灵敏度高于单独RF、AKA、CRP、抗－CCP 抗体、ANA检测(P 均<0.05)。结论：联合检测血清RF、AKA、CRP、抗－CCP 抗体、ANA水平能够大幅度提高RA的诊断灵敏度，有利于早期诊断RA。