Objective: To observe the liver function and homocysteine in patients with type 2 diabetes mellitus combined with fatty liver, and to provide the basis for the comprehensive management of clinical dia -betic patients.Methods: The medical records of patients with diabetes were collected in the Department of en -docrinology of Affiliated Hospital of Chengde Medical College from October 2012 to October 2014.All the pa-tients were divided into the experimental group (type 2 diabetes with fatty liver group 136 cases) and control group (simplex type 2 diabetes 138 cases), based on ultrasond diagnosis and clinical manifestation .The clini-cal data of the two groups, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (γ-GGT), and homocysteine (Hcy) other indicators were collected.SPSS 19.0 statistical software was used to 2 test and multivariate Logistic regression analysis .Results:① Univariate analysis of fatty liver in type 2 diabetic patients with postmenopausal women : relate to AST, ALT, γ-GGT, Hcy, there were significant differences (P<0.05).② Multivariate logistic regression analysis of fatty liver in type 2 diabetic patients with postmenopausal women :the result showed that γ-GGT (OR =5.108, 95%CI =2.802 -9.311) are all the risk factors of fatty liver.Conclusions: Liver function and Hcy are the postmenopausal factors af -fecting female type 2 diabetic patients with fatty liver.Better control of liver function and homocysteine levels may help prevent the occurrence of fatty amines .%目的：观察绝经后女性2型糖尿病合并脂肪肝患者的肝功能及同型半胱氨酸情况，为临床糖尿病患者综合管理提供依据。方法：收集2012年10月至2014年10月在承德医学院附属医院内分泌科住院诊断糖尿病患者的病历资料，将经由腹部 B 超检查并结合临床表现诊断脂肪肝的136例患者作为病例组，138例单纯2型糖尿病患者作为非病例组，收集两组患者的临床资料包括谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ－谷氨酰基转移酶（γ－GGT）、同型半胱氨酸（Hcy）各项指标，应用 SPSS19．0统计学软件进行χ2检验和多因素 Logistic 回归分析。结果：影响绝经后女性2型糖尿病患者合并脂肪肝的单因素分析：两组患者 AST、ALT、γ－GGT、Hcy 各项指标，病例组与非病例组相比，差异均有统计学意义（P＜0．05）。影响绝经后女性2型糖尿病患者合并脂肪肝的多因素 logistic 回归分析：结果显示， Hcy 并非发生脂肪肝的危险因素。结论：绝经后女性2型糖尿病患者合并脂肪肝的影响因素有肝功、Hcy，更好的控制肝功能及同型半胱氨酸水平可能有利于患者避免脂肪肝的发生。
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