盐酸替罗非班对急性心肌梗死冠脉多支病变经皮冠状动脉介入术后疗效及安全性研究

摘要

Objective:To investigate the efficacy and safety of tirofiban in patients with acute myocardial infarction after percutaneous coronary intervention. Methods:126 cases of acute myocardial infarction patients with multivessel coronary artery disease from emergency treatment in our hospital were selected, simple ran-domization,randomly divided into the control group and the experiment with 63 cases in each group according to the random number table method. Patients in the control group were treated with percutaneous coronary in-tervention;The treatment group was treated with Tirofiban Hydrochloride Injection on the basis of the control group.Two groups of patients in the postoperative unified symptomatic care.After treatment,the clinical thera-peutic effect,postoperative complications,serum C reactive protein ( CRP ),serum creatine kinase isoenzyme (CK-MB), cardiac troponin T (cTnT) levels were compared between the two groups. Results: Data show that the total incidence rate of complications of the treatment group 11. 11% was significantly lower than the control group 33.33% (P < 0.05); compared with before treatment, serum CRP, BNP, CK-MB and cTnT levels in patients decreased ( P < 0.05),the serum CRP,BNP,CK-MB,cTnT levels were lower in experi-ment group than the control group ( P <0.05) . Conclusion:The application of Tirofiban Hydrochloride Injec-tion can effectively improve the operation effect of percutaneous coronary intervention in acute myocardial in-farction patients with multivessel coronary artery disease,reduce the pain of patients,reduce the incidence of postoperative complications,control of complications have a positive effect on reducing the machine,and ser-um CRP,BNP,CK-MB and cTnT levels.%目的:探讨盐酸替罗非班的应用对接受急性心肌梗死冠脉多支病变经皮冠状动脉介入术(PCI)患者的术后疗效及安全性研究.方法:选取前来我院进行急诊治疗的126例急性心肌梗死冠脉多支病变患者作研究对象,简单随机化分组,按随机原则将其分为对照组和治疗组,每组各63例.对照组患者进行经皮冠状动脉介入术急诊治疗;治疗组在对照组治疗基础上联合使用盐酸替罗非班注射液进行救治.两组患者均于术后统一对症护理.治疗结束后对两组患者的临床治疗效果、术后并发症发生率、血清C反应蛋白(CRP)、血清肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)水平进行对比.结果:治疗组11.11%的并发症总发生率低于对照组的33.33%,差异具有统计学意义(P<0.05);与治疗前相比,患者血清CRP、BNP、CK-MB、cTnT水平降低,差异具有统计学意义(P<0.05),治疗组患者血清CRP、BNP、CK-MB、cTnT水平低于对照组(P<0.05).结论:盐酸替罗非班注射液的应用能有效提高急性心肌梗死冠脉多支病变患者经皮冠状动脉介入术的手术效果,减轻患者疼痛、降低术后并发症发生率,对患者并发症的控制有积极作用,推测其机制与血清CRP、BNP、CK-MB、cTnT水平的降低有关.