甲氧明联合麻黄碱甲氧明对老年胃癌全麻后低血压的预防作用研究

摘要

Objective:To investigate the preventive effects by ephedrine combined with methoxamine in elderly patients with gastric cancer of hypopiesia after general anesthesia. Methods:A total of 70 elderly pa-tients with gastric cancer radical operation by laparoscope after general anesthesia from our hospital , the pa-tients or their families signed an agreement, according to Simple random method was divided into the experi-ment group and control group with 35 cases in each group. patients in the control group were treated by con-ventional induction,patients in the experiment group were treated by ephedrine 6mg and methoxamine 1mg in-travenous drip ,induction of general anesthesia stage,recorded the life indexes of the two groups patients be-fore drug administration(T0) and after drug administration 5 min (T1),15 min (T2),30 min (T3), and recorded the adverse reactions of hypopiesia in anesthesia. Results:Compared with T0,the life indexes of the two groups were changed after drug administration, the systolic pressure and diastolic pressure of the experi-ment group were higher than the control group in T1, T2, T3 , systolic pressure and diastolic pressure and heart rate were lower than the control group,with statistical significance ( P <0.05),the blood oxygen satura-tion of the two groups had no changed at different time points,had no statistical significance ( P > 0.05);the hypopiesia and tachycardia incidence rate (5.71%,8.57%) were lower than the control group (22.86%,28. 57%),the difference was statistical significance ( P < 0.05),the nausea,vomiting and palpitation incidence rate of the two groups (8.57% 5.71%VS11.43% 14.29%) difference had no statistical significance ( P > 0. 05) . Conclusion:Ephedrine combine with methoxamine in the treatment of elderly patients with gastric canc-er after general anesthesia can provide a stable hemodynamic state,low incidence rate of hypopiesia,the effect is remarkable.%目的:探讨甲氧明联合麻黄碱甲氧明对老年胃癌全麻后低血压的预防作用研究.方法:选取择期行全麻下腹腔镜胃癌根治术老年患者70例,患者或家属签字同意,按简单随机法分组,对照组35例予以常规诱导,研究组35例全麻诱导阶段静脉注射麻黄碱6mg甲氧明1mg,记录两组患者给药前(T0)和给药后5min(T1)、15min(T2)、30min(T3)时不同时点的生命指标,同时记录麻醉中低血压等不良反应状况.结果:与T0比较,两组患者给药后不同时间点生命体征发生变化,研究组T1、T2、T3时收缩压和舒张压高于对照组,收缩压和舒张压心率低于对照组,具有统计学意义(P<0.05),两组患者不同时间点血氧饱和度无变化,不具有统计学意义(P>0.05);研究组低血压、心动过速发生率(5.71%、8.57%)低于对照组(22.86%、28.57%),差异有统计学意义(P<0.05),两组恶心呕吐、心悸发生率(8.57%、5.71%VS11.43%、14.29%)差异无统计学意义(P>0.05).结论:采用麻黄碱联合甲氧明应用于老年胃癌全麻能提供稳定的血流动力学状态,低血压发生率低,效果显著.