抗精神病药治疗精神分裂症后肝脏及血脂变化情况分析

摘要

目的:探讨四种抗精神病药治疗精神分裂症的疗效以及治疗后肝脏及血脂变化情况.方法:收集2015年1月至2016年2月入院的160例精神分裂症患者随机分为四组,分别给予利培酮、喹硫平、奥氮平与阿立哌唑,比较四组患者总体治疗有效率、治疗前后PANSS评分、血脂水平、脂肪肝与药物不良反应发生率.结果:四组患者总体治疗有效率与总体脂肪肝发生率不存在明显差异,不具有统计学意义(P>0.05);奥氮平组治疗后PANSS总分组间比较显著性低于喹硫平组;喹硫平组TC、TG与LDL水平组间比较显著性高于其他三组,奥氮平组TG与LDL水平组间比较显著性低于利培酮组与阿立哌唑组;喹硫平组其他不良反应发生率显著性高于其他三组,存在显著性差异,具有统计学意义(P<0.01).结论:四种抗精神病药物均可有效治疗精神分裂症,但喹硫平对血脂影响较大,不良反应率最高,而奥氮平相对疗效稳定,血脂影响小,不良反应率最低,因此可作为首要推荐药物.%Objective:To evaluate the efficacy of four kinds of antipsychotic treatment of schizophrenia and the treatment of liver and blood lipid changes.Method: 160 patients with schizophrenia who were enrolled from January 2015 to February 2016 were randomly divided into four groups: risperidone, quetiapine, olanzapine and aripiprazole group, respectively.Treatment efficiency, PANSS score before and after treatment, blood lipid levels, fatty liver and adverse drug reactions.Result: There was no significant difference between the four groups in the overall treatment rate and the overall incidence of fatty liver, and there was no statistical significance (P>0.05);After olanzapine treatment, the total score of PANSS group was significantly lower than that of quetiapine group;The levels of TC, TG and LDL in the quetiapine group were significantly higher than those in the other three groups, and the levels of TG and LDL in the olanzapine group were significantly lower than those in the risperidone group and the aripiprazole group;The incidence of other adverse reactions in quetiapine group was significantly higher than that of the other three groups, there was significant difference (P<0.01).Conclusion:Four kinds of dugs can be effective antipsychotics in the treatment of schizophrenia, but quetiapine on blood lipid influence, adverse reaction rate is the highest, while the relative efficacy of olanzapine on lipid stability, small adverse reaction rate is the lowest, so it can be recommended as the primary drug.