疏肝明目汤联合甲钴胺对肝郁气滞型原发性开角型青光眼患者眼压视敏度及CRP的影响分析

摘要

Objective:To study the impact analysis of Shugan Mingmu decoction combined with Mecobalamin on patients with liver qi stagnation primary open-angle glaucoma intraocular pressure,visual acuity and CRP.Methods: 156 cases (274 eyes) of patients with stagnation of liver Qi POAG.admitted in our hospital from January 2015 to December 2016 were selected as objects.The patients were divided into observation group 78 cases (136 eyes) and control group 78 cases (138 eyes) according to the digital method.The two patients were treated with mecobalamin.The patients in the observation group were treated with Shugan Mingmu Decoction combined mecobalamin.The IOP, visual acuity, CRP level and adverse reactions were compared between the two groups before and after treatment for 3 months.Results: The cure rate of the observation group was 57.69%,the total effective rate was 94.87%, compared with the control group of 30.77% and 84.62% were significantly higher, the difference was statistically significant(P<0.05).After treatment, the IOP reduced value and visual acuity rise value of the observation group were significantly higher than those of the control group, the difference was statistically significant(P<0.05).After treatment,the levels of CRP in the observation group was significantly lower than control group,the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of allergies, anorexia, nausea, vomiting and diarrhea, as well as adverse events in the observation group (P > 0.05).Conclusion: Using Shugan Mingmu Decoction and Mecobalamin in treatment of liver qi stagnation POAG patients with better curative effect, also can effectively improve the intraocular pressure,visual acuity and the level of CRP, which is worthy of promotion.%目的:研究分析疏肝明目汤联合甲钴胺对肝郁气滞型原发性开角型青光眼(POAG)患者眼压、视敏度及C反应蛋白(CRP)的影响.方法:选择从2015年1月到2016年12月在医院收治的156例(274眼)肝郁气滞型POAG患者纳入本次研究.依据数字法将患者划分为观察组78例(136眼)以及对照组78例(138眼).对两组患者均予以甲钴胺治疗,观察组则基于此用药方式另增加疏肝明目汤治疗,对比两组疗效,治疗前及治疗3个月后的眼压及视敏度,CRP水平以及不良反应.结果:观察组的治愈率为57.69%,总有效率为94.87%,均较对照组的30.77%及84.62%明显更高,差异均有统计学意义(均P<0.05).治疗后观察组的眼压下降值及视敏度上升值较对照组明显更大,差异有统计学意义(P<0.05).治疗后观察组的CRP水平较对照组明显更低,差异有统计学意义(P<0.05).观察组过敏、食欲不振、恶心、呕吐和腹泻,以及不良反应的总计发生率与对照组相比,差异不显著(P>0.05).结论:利用疏肝明目汤以及甲钴胺联合治疗肝郁气滞型POAG患者的疗效更佳,还可较好地改善其眼压、视敏度及CRP水平,值得推广.