Objective:To study the patients with intracranial infection after intracranial hematoma puncture drainage treatment of risk factors and analyzed.Methods:From May 2014 to July 2016 in our hospital happened after cerebral hemorrhage of puncture drainage treatment of 56 patients with intracranial infection for observe group.Another line close puncture drainage treatment did not occur in patients with intracranial infection after 58 cases as control group.Respectively compared two groups of age,diabetes mellitus,merging,hypoalbuminemia,the location of drainage tube drainage tube placement time,number of injections of urokinase,cerebrospinal fluid leakage and prevent use of antimicrobial agents.Multiariable Logistic regression analysis was carried on.Results:The average age group,the number of diabetes accounted for,the combining hypoalbuminemia number proportion respectively(65.3±11.4),73.21%(41/56),75.00%(42/56),were significantly higher than that of control group(47.2±9.3),43.10%(25/58),39.66%(23/58),differences were statistically significant(all P<0.05).Observation group of number placed on the drainage tube ventricle(ratio and mixing time number 5 d or higher than the control group,differences were statistically significant(all P<0.05).Observation group of injection of urokinase or greater than three times the number of and cerebrospinal fluid leakage rate were significantly higher than that of control group,differences were statistically significant(all P<0.05).After multiariable Logistic regression analysis,age,diabetes mellitus,merging,hypoalbuminemia,drainage tube location,time,number of injections of urokinase,cerebrospinal fluid leakage were intracranial hematoma puncture drainage after treatment of patients with intracranial infection risk factors.Conclusion:After treatment for intracranial hematoma puncture drainage in patients with intracranial infection risk factors including age,diabetes mellitus,merging,hypoalbuminemia,drainage tube location,time,number of injections of urokinase,cerebrospinal fluid leakage,etc.%目的:分析经颅内血肿穿刺引流术治疗后患者颅内感染的危险因素.方法:选取2014年5月至2016年7月于我院接受脑出血穿刺引流术治疗后发生颅内感染患者56例记为观察组.另取同期行脑出血穿刺引流术治疗后未发生颅内感染患者58例记为对照组.分别比较两组年龄、合并糖尿病、低蛋白血症、引流管位置、引流管放置时间、注射尿激酶次数、脑脊液渗漏以及预防使用抗菌药物情况,并进行多因素Logistic回归分析.结果:观察组平均年龄、合并糖尿病人数占比、合并低蛋白血症人数占比分别为(65.3±11.4)岁、73.21%(41/56)、75.00%(42/56),均显著高于对照组的(47.2±9.3)岁、43.10%(25/58)、39.66%(23/58),差异均有统计学意义(均P<0.05).观察组引流管放置于脑室人数占比及放置时间≥5d人数占比显著高于对照组,差异均有统计学意义(均P<0.05).观察组注射尿激酶≥3次人数占比以及脑脊液渗漏发生率均显著高于对照组,差异均有统计学意义(均P<0.05).经多因素Logistic回归分析发现,年龄、合并糖尿病、低蛋白血症、引流管位置、放置时间、注射尿激酶次数、脑脊液渗漏等均为颅内血肿穿刺引流术治疗后患者颅内感染的危险因素.结论:预防颅内血肿穿刺引流术后感染,需要关注患者年龄、并发症、引流管位置、放置时间、尿激酶的应用次数以及脑脊液渗漏等危险因素.
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