叶酸联合阿托伐他汀对H型高血压患者颈总动脉内膜中层厚度的影响

摘要

目的:研究叶酸联合阿托伐他汀对 H 型高血压患者颈总动脉内膜中层厚度的影响.方法:选择2016年1月至2017年7月期间我院收治的144例H型高血压患者,所有患者在近1个月内未服用降压药,随机分为观察组和对照组,给予观察组叶酸联合阿托伐他汀治疗,对照组给予阿托伐他汀治疗,随访6个月,对患者Hcy 水平、双侧颈总动脉 IMT 进行测定.结果:治疗后,两组患者的收缩压(138.71±6.93mmHg vs 141.77±10.24mmHg)和舒张压(90.82±7.12mmHg vs 94.72±6.55mmHg)相比差异 显著(P＜0.05),观察组在Hcy水平(9.82±3.11μmoL/L vs 12.32±3.18μmoL/L )和IMT(1.14±0.11mm vs 1.29±0.15mm)方面显著优于对照组,P＜0.05,差异具有统计学意义.结论:叶酸联合阿托伐他汀对于降低H型高血压患者Hcy水平、降低颈总动脉IMT的厚度具有显著的临床疗效,值得临床推广.%Objective: To study the effect of folic acid combined with atorvastatin on carotid artery inti-ma-media thickness in patients with Hypertension. Methods: A total of 144 H-type hypertensive patients ad-mitted to our hospital from January 2016 to July 2017 were enrolled in this study. All patients underwent no antihypertensive drugs in the recent 1 month and were randomly divided into observation group and control group. Group folic acid combined with atorvastatin treatment, the control group was treated with atorvastatin, 6 months follow-up, Hcy levels in patients with bilateral carotid artery IMT were measured. Results: After treat-ment, the systolic blood pressure (138.71±6.93mmHg vs 141.77±10.24mmHg) and diastolic blood pressure (90.82±7.12mmHg vs 94.72±6.55mmHg) were significantly different between the two groups (P＜0.05), and the observation group was at the level of Hcy ( 9.82±3.11umol/L vs 12.32±3.18umol/L) and IMT (1.14±0. 11mm vs 1.29±0.15mm) were significantly better than the control group, P＜0.05, and the difference was sta-tistically significant. Conclusion: Folic acid combined with atorvastatin has significant clinical efficacy in re-ducing Hcy level and decreasing IMT thickness of common carotid artery in patients with H type hypertension, which is worthy of clinical promotion.