Objective: To investigate the expression and clinical significance of integrin α2β1 protein and CD44V3 protein in cervical squamous cell carcinoma. Methods: Expression protein of integrinα2β1 and CD44V3 were detected in 80 cases of cervicals quamous cell carcinoma and normal cervical tissues 50 cases by SP method of immunohistochemistry. The correlation between the expression of two indexes in cervical squa-mous cell carcinoma and the relationship with the biological behavior of cervical squamous cell carcinoma were investigated. Result:The positive expression rates of integrin alpha 2 beta 1 protein and CD44V3 protein in cervical squamous cell carcinoma were 73.4% and 71.3%, respectively, which were all higher than those in normal cervical mucosa tissues, and the difference was statistically significant (P < 0.05). Integrin alpha 2 beta 1 protein and CD44V3 protein were significantly related to the degree of differentiation, clinical stage, lymph node metastasis and depth of invasion of cervical squamous cell carcinoma. The expression of integrin alpha 2 beta 1 protein and CD44V3 protein in the squamous cell carcinoma of the cervix was positively correla-ted (R =0.67). Conclusion:Expression of integrinα2β1 and CD44V3 protein may play an important role in the occurrence and development of cervical squamous cell carcinoma. They have positive synergy,and be used as a judgment of local invasion, distant metastasis and prognosis prediction factors of cervical squamous cell carcinoma.%目的:探讨宫颈鳞癌组织中整合素 α2β1蛋白和 CD44V3蛋白的表达及临床意义.方法:应用免疫组化方法(SP 法)检测80例宫颈鳞癌组织和50例宫颈正常黏膜组织整合素α2β1蛋白和CD44V3蛋白表达情况,探讨两指标在宫颈鳞癌组织中表达的相关性以及与宫颈鳞癌的生物学行为关系.结果:整合素α2β1蛋白和CD44V3蛋白在宫颈鳞癌组织中的阳性表达率分别为73.4%和71.3%,均高于正常宫颈黏膜组织的阳性表达率,差异有统计学意义(P<0.05);整合素α2β1蛋白和CD44V3蛋白均与宫颈鳞癌的分化程度、临床分期、淋巴结转移和浸润深度显著相关;整合素α2β1蛋白和CD44V3蛋白在宫颈鳞癌组织中的表达呈现正相关性(r=0.67).结论:整合素 α2β1蛋白和 CD44V3蛋白过表达与宫颈鳞癌的发生、发展有关,并具有正协同功能,可作为宫颈鳞癌局部浸润、远处转移及判断预后的预测因素.
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