Role of ADAM-15 Disintegrin in E-cadherin Proteolysis in Prostate Cancer Metastasis

摘要

The primary goal of this proposal was to demonstrate that the membrane disintegrin, ADAM-15, could E-cadherin in prostate cancer cells, and that in this regard ADAM-15 would promote the metastatic growth of prostate cancer. The successful completion of this study has led to the confirmation of the functional role of ADAM15 in the cleavage of E-cadherin and metastatic growth of prostate cancer cells. These results justify continuing studies examining the metalloproteinase domain of ADAM15 as a direct therapeutic target for metastatic prostate cancer.