系统性红斑狼疮患者心理障碍及影响因素分析

摘要

目的:调查系统性红斑狼疮患者心理障碍情况,并进行影响因素分析.方法:选取2012年2月至2017年4月80例系统性红斑狼疮患者为研究对象,选取同期体验的80例健康志愿者,均接受症状自评量表(SCL-90)评估,比较两组心理健康水平.根据 SCL-90筛检结果,将系统性红斑狼疮患者分为心理障碍组与无心理障碍组,比较组间年龄、性别、病程、复发次数、疾病活动性、内脏受累、药物不良反应、文化程度、职业状况、经济收入、婚姻状况、居住地等临床资料.结果:系统性红斑狼疮患者SCL-90总分为(154.29±28.51)分显著高于健康志愿者的(132.17±25.69)分(P<0.05).80例系统性红斑狼疮患者经SCL-90检出心理障碍29例,检出率为36.3%(29/80).心理障碍组病程>6个月、活动期、内脏受累、药物不良反应、高中以下文化程度、无业、经济收入<5万元/年、未婚或离异患者比例显著高于无心理障碍组(P<0.05).结论:系统性红斑狼疮患者具有较高心理障碍风险.病程、疾病活动性、内脏受累、药物不良反应、文化程度、职业状况、经济收入、婚姻状况等8个因素对系统性红斑狼疮患者心理障碍发生有显著影响.%Objective:To investigate the prevalence of psychological disorders in patients with systemic lupus erythematosus(SLE) and analyze the influencing factors. Methods:80 patients with SLE treated in our hospital during the period from February 2012 to April 2017 were selected as the subjects,and 80 healthy vol-unteers who underwent physical examination in our hospital during the same period were also enrolled in the study. All subjects were evaluated with the symptom check list-90(SCL-90),and the level of mental health was compared between the two groups. According to the results of SCL-90 screening,patients with SLE were divided into mental disorder group and no-mental disorder group. The clinical data such as age, gender, course of disease,recurrence frequency,disease activity,visceral involvement,adverse drug reactions, edu-cation level, occupation status, economic income, marital status and residence were compared between groups. Results:The total score of SCL-90 of patients with SLE was significantly higher than that of healthy volunteers [(154.29±28.51) vs (132.17±25.69) ](P < 0.05). In 80 patients with SLE, 29 patients had mental disorders detected by SCL-90,and the detection rate was 36.3% (29/80). The proportions of patients whose course of disease was longer than 6 months,patients with disease in active phase,patients with visceral involvement,patients with adverse drug reactions,patients whose education level was lower than high school, unemployed patients,patients whose income was less than 50 thousand yuan / year and unmarried or divorced patients in the mental disorders group were significantly higher than those in the non-mental disorder group(P< 0.05). Conclusion:The risk of mental disorders is relatively higher in patients with SLE. The course of dis-ease,disease activity,visceral involvement,adverse drug reactions,educational level,occupational status,e-conomic income and marital status have significant effect on the occurrence of mental disorders in patients with SLE.