不同频率rTMS对脑梗死抑郁改善情况及FTHUE-HK评级变化

摘要

目的:探讨使用不同频率的重复经颅刺激(rTMS)对脑梗死患者的抑郁情况改善以及患者偏瘫上肢功能测试(香港版)(FTHUE-HK)评级变化的影响.方法:主要选取我院在2015年9月至2016年8月收治并且符合本次实验条件的96例脑梗死患者为研究对象,将患者分成三组,分别为0.5Hz组、1Hz组、2Hz组,每组各32例.三组均使用基础的药物治疗与康复训练,在此基础上加用各组对应频率rTMS进行治疗.使用抑郁自评量表(SDS)评价三组患者治疗前后抑郁改善情况,观察患者治疗前后FTHUE-HK评级变化.结果:在治疗前,三组患者SDS评分差异无统计学意义(P>0.05),但是在治疗后,三组患者SDS评分均下降,然而0.5Hz组与2Hz组均下降到分界值以下,且组间差异无统计学意义,而1Hz组下降,但是没有其余两组显著,与其余两组相比差异具有统计学意义(P<0.05).治疗前两组FTHUE-HK评级无差异,治疗后同样为0.5Hz组与2Hz组上升且组间无差异,两组与治疗后的1Hz组差异有统计学意义(P<0.05).结论:使用不同频率的rTMS治疗脑梗死患者都能够改善患者的抑郁症状及偏瘫上肢功能,但是相比之下,高频与低频rTMS对脑梗死的治疗疗效更加显著.%Objective:To investigate the effect of repeated transcranial stimulation ( rTMS) on the improvement of depression in patients with cerebral infarction and the change of FTHUE-HK ( FTHUE-HK) rat-ing in patients with hemiplegia. Methods:96 patients with cerebral infarction who were treated in our hospital from September 2015 to August 2016 were selected and divided into three groups:0. 5Hz group, 1Hz group and 2Hz group , Each group of 32 cases. Three groups were using the basic drug therapy and rehabilitation training, on the basis of this group with the corresponding frequency rTMS for treatment. The improvement of depression in the three groups before and after treatment was evaluated by the Depression Self-Rating Scale ( SDS) . The changes of FTHUE-HK were observed before and after treatment. Results:There was no signifi-cant difference in SDS scores between the two groups before treatment ( P> 0.05) . However, after treatment, the scores of SDS in the three groups were significantly decreased, but the 0.5Hz group and the 2Hz group all dropped below the cut- (P <0.05), but there was no significant difference between the two groups (P <0. 05), but there was no significant difference between the two groups (P <0.05). There was no significant difference in FTHUE-HK between the two groups before treatment, and there was no significant difference be-tween the two groups and the 2Hz group ( P <0.05) . Conclusion:The use of different frequencies of rTMS in the treatment of cerebral infarction patients can improve the patient's depressive symptoms and hemiplegia up-per limb function, but in contrast, high frequency and low frequency rTMS treatment of cerebral infarction is more significant.