不同蛋白质饮食对慢性肾脏病患者肾功能的影响

摘要

Objective To investigate the effects of different protein diets on renal function in patients with chronic kidney diseases ( CKD ) . Methods The data of 170 patients with CKD who were outpatients of our hospital were retrospectively analyzed.According to the levels of daily protein intake ( DPI) , these patients were divided into three groups:very low protein diet (VLPD) group, with DPI≤0.6 g· kg-1 · d-1,low protein diet (LPD) group,with DPI 0.6 ~0.8 g· kg-1· d-1, normal protein diet (NPD) group, with DPI≥0.8 g· kg-1· d-1,then patient’s glomerular filtration rate was detected to compare the changes of renal function (ΔeGFR ) among the three groups.Results There were no significant differences in the incidences of protein-energy malnutrition (PEM) at different stages of CKD ( P >0.05). Pearson correlation analysis results showed that there was no significant correlation between different DPI and ΔeGFR, moreover, there were no significant differences in the effects of different DPI on ΔeGFR ( P >0.05 ) .Conclusion The intaking amount of protein has no obvious effects on renal function of patients with CKD at a certain extent.%目的：探讨不同蛋白质饮食方案对慢性肾脏病（ CKD）患者肾功能造成的影响。方法回顾性分析门诊收治并长期随访的CKD患者共170例，依据每日饮食蛋白质摄入（ DPI）对患者进行分组：极低蛋白饮食：DPI低于0构．6 g· kg－1· d－1；低蛋白饮食组：DPI 0．6～0．8 g· kg－1· d－1；普通蛋白饮食：DPI高于0．8 g· kg－1· d－1。对各组肾小球滤过率进行计算并比较各组肾功能变化（ΔeGFR ）情况。结果不同分期CKD 比较，蛋白质能量营养不良（PEM）的发生率差异无统计学意义（ P ＞0．05）。 Pearson相关分析表明，对各组分别进行比较，不同的DPI和ΔeGFR的相关性不显著，不同的DPI对ΔeGFR造成的影响其差异无统计学意义（ P ＞0．05）。结论不同含量蛋白的摄入在一定范围内不会对CKD患者的肾功能造成显著影响。