白及愈疡汤不同剂量治疗慢性非特异性溃疡性结肠炎120例临床观察

摘要

目的 观察白及愈疡汤不同剂量治疗慢性非特异性溃疡性结肠炎(CUC)的临床疗效.方法 将120例CUC患者随机分为3组,白及愈疡汤大剂量组30例、中剂量组50例、小剂量组40例,分别予白及愈疡汤600、400、200 mL/d,分早晚2次口服.3组均6周为1个疗程,治疗2个疗程后观察临床疗效、红细胞沉降率、C-反应蛋白及粪潜血.结果 白及愈疡汤中、大剂量组总有效率均高于白及愈疡汤小剂量组(P＜0.05),疗效优于白及愈疡汤小剂量组；白及愈疡汤中、大剂量组总有效率比较差异无统计学意义(P＞0.05).3组治疗后红细胞沉降率、C-反应蛋白均较治疗前降低(P＜0.05)；白及愈疡汤中、大剂量组治疗后红细胞沉降率、C-反应蛋白均较白及愈疡汤小剂量组降低明显(P＜0.05)；白及愈疡汤中、大剂量组治疗后红细胞沉降率、C -反应蛋白比较差异无统计学意义(P＞0.05).3组治疗后粪潜血阴性率高于治疗前(P＜0.05)；白及愈疡汤中、大剂量组治疗后粪潜血阴性率高于白及愈疡汤小剂量组(P＜0.05)；白及愈疡汤中、大剂量组治疗后粪潜血阴性率比较差异无统计学意义(P＞0.05).结论 白及愈疡汤中剂量组在改善临床症状、粪潜血、肠道炎症及降低红细胞沉降率方面疗效显著,增加剂量并不能增加疗效.%Objective To observe the clinical efficacy of different dose Baijiyuyang decoction on chronic non -specific ulcerative colitis (CUC). Methods 120 patients with ulcerative colitis were randomly devided into three groups,each including 40 patients. Low dose Baijiyuyang decoction group ( n =40) , middle dose Baijiyuyang decoction group ( n = 50) and high dose Baijiyuyang decoction group ( re = 30) received 200, 400 and 600 mL Baijiyuyang decoction sub twice a day. The course was six weeks in three groups, the clinical efficacy, erythrocyte sedimentation rate, CRP and were observed after two courses. Results The total effective rate in middle dose Baijiyuyang decoction group and high dose Baijiyuyang decoction group was higher than that in low dose Baijiyuyang decoction group ( P <0. 05 ). There was no significant difference between middle dose Baijiyuyang decoction group and high dose Baijiyuyang decoction group on the total effective rate ( P > 0. 05 ). Erythrocyte sedimentation rate and CRP after treatment were decreased in comparison with those before treatment in different groups ( P < 0. 05 ). E-rythrocyte sedimentation rate and CRP in middle dose Baijiyuyang decoction group and high dose Baijiyuyang decoction group was higher than that in low dose Baijiyuyang decoction group ( P <0.05). Conclusion Middle - dose Baijiyuyang decoction has better therapeutic effect on the improvement of symptoms, occult blood and intestinal inflammation and decrease of erythrocyte sedimentation rate in patient of ulcerative colitis. Increasing doses does not increase the efficacy.