目的：观察双虎清肝颗粒联合恩替卡韦片治疗慢性乙型病毒性肝炎（以下简称乙肝）的临床疗效。方法将60例乙肝患者随机分为2组，对照组30例予恩替卡韦片治疗，治疗组30例在对照组治疗基础上加用双虎清肝颗粒治疗，2组治疗第4周时观察主要症状、体征改善率，比较2组治疗6个月后丙氨酸氨基转移酶（ ALT）复常率、乙型肝炎病毒核糖核酸（ HBV-DNA）水平较基线下降率。结果治疗组治疗第4周时主要症状、体征改善率均高于对照组（P＜0．05）。治疗组治疗后 ALT复常率、HBV-DNA水平较基线下降率均高于对照组（P＜0．05）。结论双虎清肝颗粒联合恩替卡韦片治疗乙肝，在改善患者临床症状、恢复肝功能及降低HBV-DNA水平方面均有较好疗效，值得临床推广应用。%Objective To observe the clinical therapeutic effect of combination therapy of Shuanghu Qing-gan granule and entecavir tablets on chronic viral hepatitis B .Methods 60 patients with chronic hepatitis B were randomly divided into a treatment group and a control group ,with 30 patients in each group .The treatment group was given Shuanghu Qinggan granule and entecavir tablets ,and the control group was administered with entecavir tablets . After 24-weeks of treatment ,ALT normalization rates ,HBV-DNA levels and improvement of main signs and symp-toms of the two groups were compared .Results The improvement of main signs and symptoms ,ALT normalization rates、the decreased levels of HBV -DNA compared with the baseline levels in the treatment group were superior to those in the control group (P<0.05).Conclusion Combination therapy of Shuanghu Qinggan granule and ente-cavir tablets has good therapeutic effect in improvement of main signs and symptoms、recovering liver function and de-crease in levels of HBV-DNA for chronic hepatitis B ,it should be popularized .
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