ObjectiveTo explore the diagnostic evaluation of AFP、AFU、Fer、DNA-P in primary hepatocellular carcinoma(PHC).Methods Onehundred and forty cases were diuided into PHC group(n=80) and normal control group(n=60),Electrochem cuminescence method was used to detect serum AFP、AFU、Fer、DNA-P of these two groups,The sensibility and specificity of diagnosing PHC were analysed. Results The serum level of AFP、AFU、Fer、DNA-P in PHC group were significantly higher them that of in control grap(P<0.01);The sensibility of AFP、AFU、Fer for PHC were 72.5%、22.5%、68.8%、60%, The specificity of them were 95%、100%、96.3%、100%,The sensibility and specificity of these four tumor markers were 98.8% and 100%,There were significant differences in the sensibility(P<0.01). Conclusions AFP、AFU、Fer、DNA-P have some dignostic value for PHC,It especially helps to raise the diagnosis rate of PHC of negative AFP.%目的：探讨肿瘤标志物甲胎蛋白（AFP）、岩藻糖苷酶（AFU）、血清铁蛋白（Fer）和DNA多聚酶（DNA-P）联合检测在原发性肿癌（PHC）诊断中的应用价值。方法：应用电化学发光免疫分析法和全自动生化分析仪法测定80例原发性肝癌患者和60例正常对照组血清AFP、AFU、Fer和DNA-P的含量，并分析对原发性肝癌诊断的敏感性和特异性。结果：原发性肝癌组AFP、AFU、Fer和DNA-P水平明显高于正常对照组，有统计学意义（P<0.01）；AFP、AFU、Fer和DNA-P单个肿瘤标志物诊断原发性肝癌的敏感性为72.5％、22.5％、68.8％、60％，特异性为95％、100％、96.3％、100％，四种肿瘤标志物联合检测在PHC诊断中的敏感性和特异性分别为98.8％和100％，联合检测的敏感性与单项检测有统计学意义（P<0.01）。结论：AFP、AFU、Fer和DNA-P联合检测对原发性肝癌有一定的诊断价值，尤其可提高AFP阴性原发性肝癌的诊断率。
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