Objective To investigate the curative effect of atorvastatin combined with captopril in the treatment of hypertension patients and the influence on the levels of blood pressure, carotid artery IMT and serum ET-1, NO, IL-6.Methods 92 cases of hypertension patients in our hospital from Sep.2016 to Sep.2017 were divided into the common group (n=46, captopril treatment) and the combination group (n=46, atorvastatin combined with captopril treatment) according to the odd or even number method.The clinical effect after 6 months, the blood pressure before and after treatment, the carotid artery IMT, serum ET-1, NO, IL-6 of the two groups were observed.Results At 6 months after treatment, the total effective rates of the common group and the combination group were 71.7％, 89.3％ respectively, the difference between the two groups was statistic significant (P＜0.05);at 6 months after treatment, the levels of carotid artery IMT and serum ET-1, NO, IL-6 were all significantly declined (P＜0.05), serum NO level was significantly increased (P＜0.05), the decrease or increase degree of the combination group was significantly larger than that of the control group (P＜0.05);no obvious adverse reactions occurred in the two groups during the treatment.Conclusion Atorvastatin combined with captopril in the treatment of hypertension patients can significantly improve the fluctuation of blood pressure, vascular endothelial state and microinflammatory status, reduce the carotid atherosclerosis progress, the clinical effect is significant and it is worthy of application.%目的 研究阿托伐他汀联合卡托普利治疗高血压患者疗效及对血压水平、颈动脉内-中膜厚度(IMT)和血清内皮素-1(ET-1)、一氧化氮(NO)、白介素6(IL-6)水平的影响.方法 按照单双号法将我院2016年9月至2017年9月收治的92例高血压患者分为常规组(n=46,应用卡托普利治疗)与联合组(n=46,应用阿托伐他汀联合卡托普利治疗),观察两组患者治疗6个月后的临床疗效、治疗前后血压水平、颈动脉IMT、血清ET-1、NO、IL-6水平变化.结果 常规组与联合组治疗6个月后总有效率分别为71.7％、89.3％,差异有统计学意义(P＜0.05);治疗6个月后,两组颈动脉IMT水平、血清ET-1、IL-6水平均显著降低(P＜0.05),血清NO水平显著升高(P＜0.05),且联合组降低或升高幅度显著大于常规组(P＜0.05);治疗期间,两组患者均未见明显不良反应.结论 阿托伐他汀联合卡托普利治疗高血压,可明显改善患者血压波动、血管内皮状态与微炎症反应,缓解患者劲动脉粥样硬化进程,临床疗效显著.
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