前列腺素E1联合脱氧核苷酸钠治疗儿童急性肾损伤疗效观察

摘要

To explore the efficacy of prostaglandin El combined with deoxyribo-nuclcotide natrium in the treatment of children with acute kidney injury (AKI). Methods The patients were divided into the following four groups: control group (20 cases, conventional therapy); prostaglandin El group (20 cases, conventional theraFY combined with 0.2μg· kg-1· d-1 prostaglandin El intravenously); Deoxyribonuclcotide natrium group(20 cases, conventional therapy combined with lmg.kg-1·d-1 deoxyribonucleotide natrium intravenously); Prostaglandin E1+ denxyribonuclentide natrium group (20 cases, conventional therapy combined with 0.21ag·kg-1·d-1 prostaglandin E: and lμg.kg-1·d-1 deoxyribonucleotide natrium intravenously). Results The recovery rate of combined treatment group and control group were 85％, 60％, respectively(P＜0.05). A synergestic effects of prostaglandin El and deoxyribonucleotide natrium were observed in the duration of oliguria stage (P＜0.05), recovery time of Scr (P＜0.05), the level of urinary β2-MG (P＜0.05) and urine osmotic pressure (P＜0.01) when compared with prostaglandin El and deoxyribonuclentide natrium group. Conclusion There were a synergcstic effects ofprostaglandin El and deoxyribonuclcotide natrium in the treatmere of children with acute kidney injury.%目的 探讨前列腺素E1联合脱氧核苷酸钠治疗儿童急性肾损伤(AKI)的疗效.方法 实验分组:①对照组(20例,常规治疗);②前列腺素E1治疗组(20例,常规治疗基础上加用前列腺素E10.2 μg/kg,静脉滴注1次/d);③脱氧核苷酸钠治疗组(20例,常规治疗基础上加用脱氧核苷酸钠l mg/kg,静脉滴注1次/d);④前列腺素E1联合脱氧核苷酸钠治疗组(20例,用法用量同前),总疗程4周.结果 联合组和对照组治愈率分别为85%、60%,差异有统计学意义(P＜ 0.05).联合组少尿期持续时间、Scr恢复时间均较单用前列腺素E1或脱氧核苷酸钠治疗组短(P＜0.05);联合组尿β2-MG水平显著低于单用前列腺素E1或脱氧核苷酸钠治疗组(P＜0.05),联合组尿渗透压水平显著高于单用前列腺素E1或脱氧核苷酸钠治疗组(P＜0.01).结论 前列腺素E1联合脱氧核苷酸钠对儿童AKI疗效肯定,优于单用前列腺素E1或单用脱氧核苷酸钠,提示联用前列腺素E1及脱氧核苷酸钠对儿童AKI有协同治疗效应.