Through detection the urine cystafin C, a1-MG, NAG andβ2-MG to evaluate the function of renal tubular in patients. Methods 222 subjects with kidney disease were selected as case group from January 2010 to December 2010, 50 subjects of healthy people for the outpatient were selected as control group. Two groups were examined with urine cystatin C, α1-MG, NAG and β2-MG in the determination of content by ELISA, and results were compared and statistically analyzed. Results The levels of urine cystatin C, α1-MG, NAG and β2-MG in case group were significantly higher than those in control group, and the differences showed statistically significant (P＜0.001), the area under the curve of urine cystatin C was 0.756, 95％ confidence interval was 0.628～0.885, more sensitive (P＜0.001). Conclusion The content of urine cystatin C, α1-MG, NAG andβ2-MG had an important clinical significance in the evaluation of renal tubular function in patients, and it could be regarded as an efficiency index of the early diagnosis, effect observation and justice prognosis in renal tubular injury.%目的 通过检测尿液胱蛋白酶抑制剂C(Cystatin C)、α1-微量球蛋白(α1-MG)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)和β2-微球蛋白(β2-MG),从而评价患者的肾小管功能.方法 选择2010年1月至2010年12月在我科住院的患者222例为病例组,健康体检者50例为对照组.采用酶联免疫法检测两组尿Cystatin C、α1-MG、NAG和β2-MG的测定含量,并对检测结果进行比较及统计学分析.结果 病例组尿液中的CystatinC、α1-MG、NAG、β2-MG、的测定含量明显高于正常对照组,差异具有统计学意义(P<0.001),尿Cystatin C曲线下面积为0.756,95%可信区间是0.628～0.885更具有敏感性(P<0.001).结论 尿液中Cystatin C、α-MG、NAG和β2-MG的含量对评价患者肾小管功能具有重要的临床意义,可以作为肾小管损伤性疾病的早期诊断、疗效观察和预后判断的有效指标.
展开▼
