重组人脑钠利肽治疗顽固性心衰31例临床观察

摘要

目的 观察本院2008年8月～2010年10月以来应用重组人脑钠利肽治疗的顽固性心衰31例,分析治疗成败的因素,总结治疗的经验,以便提高治疗水平.方法 31例顽固性心衰患者,给予标准抗心衰治疗基础上,应用重组人脑钠利肽进行治疗,观察临床症状、体征等方面临床治疗效果及临床转归.结果 治疗好转出院26例,自动出院4例,死亡1例.结论 应用重组人脑钠利肽治疗顽固性心衰,临床症状、体征等方面效果显著,不良反应只有剂量依赖性的低血压,有较好的安全性和耐受性,值得在顽固性心衰患者中应用.%Objective To observe the benefit of human brain natriuretic peptide (rhBNP) in the treatment of refractory heart failure, and summarize the experience of treatment in order to improve the treatment level. Methods 31 patients with refractory heart failure were given rhBNP for treatment based on standard anti-heart failure therapy,and clinical symptoms, signs and other aspects of clinical treatment and clinical outcome were observed and recorded.Results 26 patients improved, 4 cases automatic discharged, and 1 died. Conclusion rhBNP is significantly effective to treat refractory heart failure, with good tolerability except dose-dependent adverse effects of hypotension.